Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
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s41418-017-0012-4.pdf
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2.77 MB
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Adobe PDF
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Author(s)
Vander Heiden, Matthew G.
Date Issued
January 2018
Journal
Cell Death & Differentiation
Publisher
Nature Publishing Group
Citation
Galluzzi, Lorenzo et al. “Molecular Mechanisms of Cell Death: Recommendations of the Nomenclature Committee on Cell Death 2018.” Cell Death & Differentiation 25, 3 (January 2018): 486–541 © 2018 ADMC Associazione Differenziamento e Morte Cellulare
Version
Final published version
Abstract
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
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DOI of Published Version
https://doi.org/10.1038/s41418-017-0012-4
