Temperature-responsive biometamaterials for gastrointestinal applications
Name
Temperature-responsive_biometamaterials_for_gastro.pdf
Description
Published version
Size
1.22 MB
Format
Adobe PDF
Checksum (MD5)
d75821f5f9160fe1a1fe0fdbb0393ad8
Author(s)
Babaee, Sahab
Pajovic, Simo
Kirtane, Ameya
Shi, Jiuyun
Caffarel Salvador, Ester
Hess, Kaitlyn
Collins, Joy E
Tamang, Siddartha M
Wahane, Aniket Vijay
Hayward, Alison M
Date Issued
April 2019
Journal
Science Translational Medicine
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Babaee, Sahab et al. "Temperature-responsive biometamaterials for gastrointestinal applications." Science Translational Medicine 11, 488 (April 2019): eaau8581 © 2019 The Authors
Version
Final published version
Abstract
We hypothesized that ingested warm fluids could act as triggers for biomedical devices. We investigated heat dissipation throughout the upper gastrointestinal (GI) tract by administering warm (55°C) water to pigs and identified two zones in which thermal actuation could be applied: esophageal (actuation through warm water ingestion) and extra-esophageal (protected from ingestion of warm liquids and actuatable by endoscopically administered warm fluids). Inspired by a blooming flower, we developed a capsule-sized esophageal system that deploys using elastomeric elements and then recovers its original shape in response to thermal triggering of shape-memory nitinol springs by ingestion of warm water. Degradable millineedles incorporated into the system could deliver model molecules to the esophagus. For the extra-esophageal compartment, we developed a highly flexible macrostructure (mechanical metamaterial) that deforms into a cylindrical shape to safely pass through the esophagus and deploys into a fenestrated spherical shape in the stomach, capable of residing safely in the gastric cavity for weeks. The macrostructure uses thermoresponsive elements that dissociate when triggered with the endoscopic application of warm (55°C) water, allowing safe passage of the components through the GI tract. Our gastric-resident platform acts as a gram-level long-lasting drug delivery dosage form, releasing small-molecule drugs for 2 weeks. We anticipate that temperature-triggered systems could usher the development of the next generation of stents, drug delivery, and sensing systems housed in the GI tract.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Massachusetts Institute of Technology. Division of Comparative Medicine
Massachusetts Institute of Technology. Department of Mechanical Engineering
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1126/scitranslmed.aau8581
