Next-generation transgenic mice for optogenetic analysis of neural circuits
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Asrican-2013-Next-generation tran.pdf
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Author(s)
Asrican, Brent
Augustine, George J.
Berglund, Ken
Chen, Susu
Chow, Nick
Deisseroth, Karl
Feng, Guoping
Gloss, Bernd
Hira, Riichiro
Hoffmann, Carolin
Date Issued
November 2013
Journal
Frontiers in Neural Circuits
Publisher
Frontiers Research Foundation
Citation
Asrican, Brent, George J. Augustine, Ken Berglund, Susu Chen, Nick Chow, Karl Deisseroth, Guoping Feng, et al. “Next-Generation Transgenic Mice for Optogenetic Analysis of Neural Circuits.” Front. Neural Circuits 7 (2013).
Version
Final published version
Abstract
Here we characterize several new lines of transgenic mice useful for optogenetic analysis of brain circuit function. These mice express optogenetic probes, such as enhanced halorhodopsin or several different versions of channelrhodopsins, behind various neuron-specific promoters. These mice permit photoinhibition or photostimulation both in vitro and in vivo. Our results also reveal the important influence of fluorescent tags on optogenetic probe expression and function in transgenic mice.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.3389/fncir.2013.00160
