Fluid flow in the sarcomere
Name
2106.08476.pdf
Description
Accepted version
Size
7.91 MB
Format
Unknown
Checksum (MD5)
bede56f6091b762b19459b9ef8bba967
Author(s)
Malingen, Sage A
Hood, Kaitlyn Tuley
Lauga, Eric
Hosoi, Anette E.
Daniel, Thomas L
Date Issued
2021
Journal
Archives of Biochemistry and Biophysics
Publisher
Elsevier BV
Citation
Malingen, Sage A, Hood, Kaitlyn, Lauga, Eric, Hosoi, Anette and Daniel, Thomas L. 2021. "Fluid flow in the sarcomere." Archives of Biochemistry and Biophysics, 706.
Version
Author's final manuscript
Abstract
A highly organized and densely packed lattice of molecular machinery within the sarcomeres of muscle cells powers contraction. Although many of the proteins that drive contraction have been studied extensively, the mechanical impact of fluid shearing within the lattice of molecular machinery has received minimal attention. It was recently proposed that fluid flow augments substrate transport in the sarcomere, however, this analysis used analytical models of fluid flow in the molecular machinery that could not capture its full complexity. By building a finite element model of the sarcomere, we estimate the explicit flow field, and contrast it with analytical models. Our results demonstrate that viscous drag forces on sliding filaments are surprisingly small in contrast to the forces generated by single myosin molecular motors. This model also indicates that the energetic cost of fluid flow through viscous shearing with lattice proteins is likely minimal. The model also highlights a steep velocity gradient between sliding filaments and demonstrates that the maximal radial fluid velocity occurs near the tips of the filaments. To our knowledge, this is the first computational analysis of fluid flow within the highly structured sarcomere.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.ABB.2021.108923
