Neuron–Glial Interactions: Implications for Plasticity, Behavior, and Cognition
Name
e1231242024.full.pdf
Description
Published version
Size
542.16 KB
Format
Adobe PDF
Checksum (MD5)
74030b7e3199796c93ea111942422874
Author(s)
Rangel-Gomez, Mauricio
Alberini, Cristina M
Deneen, Benjamin
Drummond, Gabrielle T
Manninen, Tiina
Sur, Mriganka
Vicentic, Aleksandra
Date Issued
October 2, 2024
Journal
The Journal of Neuroscience
Publisher
Society for Neuroscience
Citation
Mauricio Rangel-Gomez, Cristina M. Alberini, Benjamin Deneen, Gabrielle T. Drummond, Tiina Manninen, Mriganka Sur, Aleksandra Vicentic
Journal of Neuroscience 2 October 2024, 44 (40) e1231242024.
Version
Final published version
Abstract
The traditional view of glial cells as mere supportive tissue has shifted, due to advances in technology and theoretical conceptualization, to include a diversity of other functions, such as regulation of complex behaviors. Astrocytes, the most abundant glial cells in the central nervous system (CNS), have been shown to modulate synaptic functions through gliotransmitter-mediated neurotransmitter reuptake, influencing neuronal signaling and behavioral functions. Contemporary studies further highlight astrocytes’ involvement in complex cognitive functions. For instance, inhibiting astrocytes in the hippocampus can lead to memory deficits, suggesting their integral role in memory processes. Moreover, astrocytic calcium activity and astrocyte–neuron metabolic coupling have been linked to changes in synaptic strength and learning. Microglia, another type of glial cell, also extend beyond their supportive roles, contributing to learning and memory processes, with microglial reductions impacting these functions in a developmentally dependent manner. Oligodendrocytes, traditionally thought to have limited roles postdevelopment, are now recognized for their activity-dependent modulation of myelination and plasticity, thus influencing behavioral responses. Recent advancements in technology and computational modeling have expanded our understanding of glial functions, particularly how astrocytes influence neuronal circuits and behaviors. This review underscores the importance of glial cells in CNS functions and the need for further research to unravel the complexities of neuron–glia interactions, the impact of these interactions on brain functions, and potential implications for neurological diseases.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1523/JNEUROSCI.1231-24.2024
