A Robust Method for Perfusable Microvascular Network Formation In Vitro
Name
Small Methods - 2022 - Wan - A Robust Method for Perfusable Microvascular Network Formation In Vitro.pdf
Description
Published version
Size
6.95 MB
Format
Adobe PDF
Checksum (MD5)
fcf91c9c20ef5e16d2c11b61432b52a5
Author(s)
Wan, Zhengpeng
Zhong, Amy X
Zhang, Shun
Pavlou, Georgios
Coughlin, Mark F
Shelton, Sarah E
Nguyen, Huu Tuan
Lorch, Jochen H
Barbie, David A
Kamm, Roger D
Date Issued
April 3, 2022
Journal
Small Methods
Publisher
Wiley
Citation
Wan, Zhengpeng, Zhong, Amy X, Zhang, Shun, Pavlou, Georgios, Coughlin, Mark F et al. 2022. "A Robust Method for Perfusable Microvascular Network Formation In Vitro." Small Methods.
Version
Final published version
Abstract
Micropost-based microfluidic devices are widely used for microvascular network (MVN) formation in diverse research fields. However, consistently generating perfusable MVNs of physiological morphology and dimension has proven to be challenging. Here, how initial seeding parameters determine key characteristics of MVN formation is investigated and a robust two-step seeding strategy to generate perfusable physiological MVNs in microfluidic devices is established.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licens
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/smtd.202200143
