Compatibility with Killer Explains the Rise of RNAi-Deficient Fungi
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Bartel_Compatibility with killer.pdf
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Author(s)
Drinnenberg, Ines A.
Bartel, David
Fink, Gerald R
Date Issued
September 2011
Journal
Science
Publisher
American Association for the Advancement of Science
Citation
Drinnenberg, I. A., G. R. Fink, and D. P. Bartel. “Compatibility with Killer Explains the Rise of RNAi-Deficient Fungi.” Science 333, no. 6049 (September 15, 2011): 1592-1592.
Version
Author's final manuscript
Abstract
The RNA interference (RNAi) pathway is found in most eukaryotic lineages but curiously is absent in others, including that of Saccharomyces cerevisiae. We show that reconstituting RNAi in S. cerevisiae causes loss of a beneficial double-stranded RNA virus known as killer virus. Incompatibility between RNAi and killer viruses extends to other fungal species in that RNAi is absent in all species known to possess double-stranded RNA killer viruses, whereas killer viruses are absent in closely related species that retained RNAi. Thus, the advantage imparted by acquiring and retaining killer viruses explains the persistence of RNAi-deficient species during fungal evolution.
MIT Department
Massachusetts Institute of Technology. Department of Biology
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1126/science.1209575
