Young Dentate Granule Cells Mediate Pattern Separation, whereas Old Granule Cells Facilitate Pattern Completion
Name
Nakashiba-2012-Young Dentate Granul.pdf
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2.26 MB
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Checksum (MD5)
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Author(s)
Nakashiba, Toshiaki
Cushman, Jesse D.
Pelkey, Kenneth A.
Renaudineau, Sophie
Buhl, Derek L.
McHugh, Thomas J.
Barrera, Vanessa Rodriguez
Chittajallu, Ramesh
Iwamoto, Keisuke S.
McBain, Chris J.
Date Issued
March 2012
Journal
Cell
Publisher
Elsevier B.V.
Citation
Nakashiba, Toshiaki, Jesse D. Cushman, Kenneth A. Pelkey, Sophie Renaudineau, Derek L. Buhl, Thomas J. McHugh, Vanessa Rodriguez Barrera, et al. “Young Dentate Granule Cells Mediate Pattern Separation, Whereas Old Granule Cells Facilitate Pattern Completion.” Cell 149, no. 1 (March 2012): 188–201.© 2012 Elsevier Inc.
Version
Final published version
Abstract
Adult-born granule cells (GCs), a minor population of cells in the hippocampal dentate gyrus, are highly active during the first few weeks after functional integration into the neuronal network, distinguishing them from less active, older adult-born GCs and the major population of dentate GCs generated developmentally. To ascertain whether young and old GCs perform distinct memory functions, we created a transgenic mouse in which output of old GCs was specifically inhibited while leaving a substantial portion of young GCs intact. These mice exhibited enhanced or normal pattern separation between similar contexts, which was reduced following ablation of young GCs. Furthermore, these mutant mice exhibited deficits in rapid pattern completion. Therefore, pattern separation requires adult-born young GCs but not old GCs, and older GCs contribute to the rapid recall by pattern completion. Our data suggest that as adult-born GCs age, their function switches from pattern separation to rapid pattern completion.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
RIKEN-MIT Center for Neural Circuit Genetics
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.cell.2012.01.046
