Me[subscript 3](OMe)tBuXPhos: A Surrogate Ligand for Me[subscript 4]tBuXPhos in Palladium-Catalyzed C-N and C-O Bond-Forming Reactions
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Buchwald_Me-3 (Ome).pdf
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Author(s)
Ueda, Satoshi
Fors, Brett P.
Ali, Siraj Z.
Buchwald, Stephen Leffler
Date Issued
February 2012
Journal
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Citation
Ueda, Satoshi, Siraj Ali, Brett P. Fors, and Stephen L. Buchwald. “Me3(OMe)tBuXPhos: A Surrogate Ligand for Me4tBuXPhos in Palladium-Catalyzed C–N and C–O Bond-Forming Reactions.” The Journal of Organic Chemistry 77, no. 5 (March 2, 2012): 2543-2547.
Version
Author's final manuscript
Abstract
A new biarylphosphine ligand, Me[subscript 3](OMe)tBuXPhos (L3), was designed as a surrogate for Me[subscript 4]tBuXPhos (L1). The Me[subscript 3](OMe)tBuXPhos could be prepared in a chromatography-free manner from inexpensive and readily available 2,3,6-trimethylphenol. Comparative studies demonstrated that a catalyst based on Me[subscript 3](OMe)tBuXPhos displayed the same reactivity as a catalyst based on Me[subscript 4]tBuXPhos for Pd-catalyzed C–N and C–O bond-forming processes.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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DOI of Published Version
https://doi.org/10.1021/jo202537e
