Direct visualization of the perforant pathway in the human brain with ex vivo diffusion tensor imaging
Name
Direct vistualization of the perforant pathway.pdf
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2.12 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Augustinack, Jean
Helmer, Karl G.
Huber, Kristen E.
Kakunoori, Sita
Zollei, Lilla
Fischl, Bruce
Date Issued
May 2010
Journal
Frontiers in Human Neuroscience
Publisher
Frontiers Research Foundation
Citation
Augustinack Jean C., et al. "Direct visualization of the perforant pathway in the human brain with ex vivo diffusion tensor imaging." Front. Hum. Neurosci. 4:42.
Version
Final published version
Abstract
Ex vivo magnetic resonance imaging yields high resolution images that reveal detailed cerebral anatomy and explicit cytoarchitecture in the cerebral cortex, subcortical structures, and white matter in the human brain. Our data illustrate neuroanatomical correlates of limbic circuitry with high resolution images at high field. In this report, we have studied ex vivo medial temporal lobe samples in high resolution structural MRI and high resolution diffusion MRI. Structural and diffusion MRIs were registered to each other and to histological sections stained for myelin for validation of the perforant pathway. We demonstrate probability maps and fiber tracking from diffusion tensor data that allows the direct visualization of the perforant pathway. Although it is not possible to validate the DTI data with invasive measures, results described here provide an additional line of evidence of the perforant pathway trajectory in the human brain and that the perforant pathway may cross the hippocampal sulcus.
MIT Department
Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.3389/fnhum.2010.00042
