Membrane-less microfiltration using inertial microfluidics
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Warkiani-2015-Membrane-less microfiltration.pdf
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Author(s)
Warkiani, Majid Ebrahimi
Tay, Andy Kah Ping
Guan, Guofeng
Han, Jongyoon
Date Issued
July 2015
Journal
Scientific Reports
Publisher
Nature Publishing Group
Citation
Warkiani, Majid Ebrahimi, Andy Kah Ping Tay, Guofeng Guan, and Jongyoon Han. “Membrane-Less Microfiltration Using Inertial Microfluidics.” Scientific Reports 5 (July 8, 2015): 11018.
Version
Final published version
Abstract
Microfiltration is a ubiquitous and often crucial part of many industrial processes, including biopharmaceutical manufacturing. Yet, all existing filtration systems suffer from the issue of membrane clogging, which fundamentally limits the efficiency and reliability of the filtration process. Herein, we report the development of a membrane-less microfiltration system by massively parallelizing inertial microfluidics to achieve a macroscopic volume processing rates (~ 500 mL/min). We demonstrated the systems engineered for CHO (10–20 μm) and yeast (3–5 μm) cells filtration, which are two main cell types used for large-scale bioreactors. Our proposed system can replace existing filtration membrane and provide passive (no external force fields), continuous filtration, thus eliminating the need for membrane replacement. This platform has the desirable combinations of high throughput, low-cost, and scalability, making it compatible for a myriad of microfiltration applications and industrial purposes.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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DOI of Published Version
https://doi.org/10.1038/srep11018
