The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond
Name
Fedeles-etal-Essigmann-2015-JBC-AlkB-minireview.pdf
Description
main article
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800.18 KB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Fedeles, Bogdan I.
Singh, Vipender
Delaney, James C.
Li, Deyu
Essigmann, John M.
Date Issued
July 2015
Journal
Journal of Biological Chemistry
Publisher
American Society for Biochemistry and Molecular Biology (ASBMB)
Citation
Fedeles, Bogdan I., Vipender Singh, James C. Delaney, Deyu Li, and John M. Essigmann. “The AlkB Family of Fe(II)/α-Ketoglutarate-Dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond.” J. Biol. Chem. 290, no. 34 (July 7, 2015): 20734–20742.
Version
Author's final manuscript
Abstract
The AlkB family of Fe(II)- and α-ketoglutarate-dependent dioxygenases is a class of ubiquitous direct reversal DNA repair enzymes that remove alkyl adducts from nucleobases by oxidative dealkylation. The prototypical and homonymous family member is an Escherichia coli “adaptive response” protein that protects the bacterial genome against alkylation damage. AlkB has a wide variety of substrates, including monoalkyl and exocyclic bridged adducts. Nine mammalian AlkB homologs exist (ALKBH1–8, FTO), but only a subset functions as DNA/RNA repair enzymes. This minireview presents an overview of the AlkB proteins including recent data on homologs, structural features, substrate specificities, and experimental strategies for studying DNA repair by AlkB family proteins.
MIT Department
Massachusetts Institute of Technology. Center for Environmental Health Sciences
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Chemistry
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DOI of Published Version
https://doi.org/10.1074/jbc.R115.656462
