Cytoskeletal Dynamics and Transport in Growth Cone Motility and Axon Guidance
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Gertler_Cytoskeletal dynamics.pdf
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592.12 KB
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Author(s)
Dent, Erik W.
Gertler, Frank
Date Issued
October 2003
Journal
Neuron
Publisher
Elsevier
Citation
Dent, Erik W, and Frank B Gertler. “Cytoskeletal Dynamics and Transport in Growth Cone Motility and Axon Guidance.” Neuron 40.2 (2003): 209–227. Copyright © 2003 Cell Press.
Version
Final published version
Abstract
Recent studies indicate the actin and microtubule cytoskeletons are a final common target of many signaling cascades that influence the developing neuron. Regulation of polymer dynamics and transport are crucial for the proper growth cone motility. This review addresses how actin filaments, microtubules, and their associated proteins play crucial roles in growth cone motility, axon outgrowth, and guidance. We present a working model for cytoskeletal regulation of directed axon outgrowth. An important goal for the future will be to understand the coordinated response of the cytoskeleton to signaling cascades induced by guidance receptor activation.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/S0896-6273(03)00633-0
