Similar Risk of Depression and Anxiety Following Surgery or Hospitalization for Crohn's Disease and Ulcerative Colitis
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Szolovits_Similar risk.pdf
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Author(s)
Ananthakrishnan, Ashwin N.
Gainer, Vivian
Cai, Tianxi
Perez, Raul Guzman
Cheng, Su-Chun
Savova, Guergana
Chen, Pei
Szolovits, Peter
Xia, Zongqi
De Jager, Philip L.
Date Issued
January 2013
Journal
The American Journal of Gastroenterology
Publisher
Nature Publishing Group
Citation
Ananthakrishnan, Ashwin N, Vivian S Gainer, Tianxi Cai, Raul Guzman Perez, Su-Chun Cheng, Guergana Savova, Pei Chen, et al. “Similar Risk of Depression and Anxiety Following Surgery or Hospitalization for Crohn’s Disease and Ulcerative Colitis.” Am J Gastroenterol 108, no. 4 (January 22, 2013): 594–601.
Version
Author's final manuscript
Abstract
OBJECTIVES:
Psychiatric comorbidity is common in Crohn's disease (CD) and ulcerative colitis (UC). Inflammatory bowel disease (IBD)-related surgery or hospitalizations represent major events in the natural history of the disease. The objective of this study is to examine whether there is a difference in the risk of psychiatric comorbidity following surgery in CD and UC.
METHODS:
We used a multi-institution cohort of IBD patients without a diagnosis code for anxiety or depression preceding their IBD-related surgery or hospitalization. Demographic-, disease-, and treatment-related variables were retrieved. Multivariate logistic regression analysis was performed to individually identify risk factors for depression and anxiety.
RESULTS:
Our study included a total of 707 CD and 530 UC patients who underwent bowel resection surgery and did not have depression before surgery. The risk of depression 5 years after surgery was 16% and 11% in CD and UC patients, respectively. We found no difference in the risk of depression following surgery in the CD and UC patients (adjusted odds ratio, 1.11; 95% confidence interval, 0.84–1.47). Female gender, comorbidity, immunosuppressant use, perianal disease, stoma surgery, and early surgery within 3 years of care predicted depression after CD surgery; only the female gender and comorbidity predicted depression in UC patients. Only 12% of the CD cohort had ≥4 risk factors for depression, but among them nearly 44% subsequently received a diagnosis code for depression.
CONCLUSIONS:
IBD-related surgery or hospitalization is associated with a significant risk for depression and anxiety, with a similar magnitude of risk in both diseases.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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DOI of Published Version
https://doi.org/10.1038/ajg.2012.471
