Copper Hydride Catalyzed Hydroamination of Alkenes and Alkynes
Name
Buchwald_Copper hydride.pdf
Size
1.54 MB
Format
Adobe PDF
Checksum (MD5)
9c69e7bddc166ceb388fd5da3371cdcc
Author(s)
Pirnot, Michael T
Wang, Yiming
Buchwald, Stephen Leffler
Date Issued
December 2015
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Pirnot, Michael T., Yi-Ming Wang, and Stephen L. Buchwald. “Copper Hydride Catalyzed Hydroamination of Alkenes and Alkynes.” Angewandte Chemie International Edition 55.1 (2016): 48–57.
Version
Author's final manuscript
Abstract
Over the past few years, CuH-catalyzed hydroamination has been discovered and developed as a robust and conceptually novel approach for the synthesis of enantioenriched secondary and tertiary amines. The success in this area of research was made possible through the large body of precedent in copper(I) hydride catalysis and the well-explored use of hydroxylamine esters as electrophilic amine sources in related copper-catalyzed processes. This Minireview details the background, advances, and mechanistic investigations in CuH-catalyzed hydroamination.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/anie.201507594
