A Voxel-Based Monte Carlo Model of Drug Release from Bulk Eroding Nanoparticles
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Sasisekharan_A voxel-based.pdf
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Author(s)
Eavarone, David A.
Soundararajan, Venkataramanan
Haller, Toomas
Sasisekharan, Ram
Date Issued
September 2010
Journal
Journal of Nanoscience and Nanotechnology
Publisher
American Scientific Publishers
Citation
Eavarone, David A., Venkataramanan Soundararajan, Toomas Haller, and Ram Sasisekharan. “A Voxel-Based Monte Carlo Model of Drug Release from Bulk Eroding Nanoparticles.” Journal of Nanoscience and Nanotechnology 10, no. 9 (September 1, 2010): 5903–5907.
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Author's final manuscript
Abstract
The use of polymeric nanoparticles as drug delivery devices is becoming increasingly prevalent in a variety of therapeutic applications. Despite their widespread clinical use, the factors influencing the release profiles of nanoparticle-encapsulated drugs are still not quantitatively understood. We present here a new, semi-empirical model of drug release from polymeric nanoparticles using a formulation of dexamethasone encapsulated within poly(lactic-co-glycolic acid) to set model parameters. We introduce a three-dimensional voxel-based framework for Monte Carlo simulations that enables direct investigation of the entire spherical nanoparticle during particle degradation and drug release. Due to implementation of this model at the nanoscale, we utilize assumptions that simplify the model while still allowing multi-phase drug release to be simulated with good correlation to experimental results. In the future, emerging mechanistic understandings of nanoparticle drug release may be integrated into this simulation framework to increase predictive power.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Biological Engineering
Koch Institute for Integrative Cancer Research at MIT
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DOI of Published Version
https://doi.org/10.1166/jnn.2010.2456
