Differential Dynamics of Activity Changes in Dorsolateral and Dorsomedial Striatal Loops during Learning
Name
Thorn-2010-Differential Dynamic.pdf
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2.49 MB
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Author(s)
Thorn, Catherine A.
Atallah, Hicham
Howe, Mark William
Graybiel, Ann M.
Date Issued
June 2010
Journal
Neuron
Publisher
Elsevier
Citation
Thorn, Catherine A., Hisham Atallah, Mark Howe, and Ann M. Graybiel. “Differential Dynamics of Activity Changes in Dorsolateral and Dorsomedial Striatal Loops During Learning.” Neuron 66, no. 5 (June 2010): 781–795. © 2010 Elsevier Inc.
Version
Final published version
Abstract
The basal ganglia are implicated in a remarkable range of functions influencing emotion and cognition as well as motor behavior. Current models of basal ganglia function hypothesize that parallel limbic, associative, and motor cortico-basal ganglia loops contribute to this diverse set of functions, but little is yet known about how these loops operate and how their activities evolve during learning. To address these issues, we recorded simultaneously in sensorimotor and associative regions of the striatum as rats learned different versions of a conditional T-maze task. We found highly contrasting patterns of activity in these regions during task performance and found that these different patterns of structured activity developed concurrently, but with sharply different dynamics. Based on the region-specific dynamics of these patterns across learning, we suggest a working model whereby dorsomedial associative loops can modulate the access of dorsolateral sensorimotor loops to the control of action.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
McGovern Institute for Brain Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.neuron.2010.04.036
