FRET-enabled biological characterization of polymeric micelles
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Hammond_EMB until May 2016 FRET-enabled.pdf
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Author(s)
Morton, Stephen Winford
Zhao, Xiaoyong
Quadir, Mohiuddin Abdul
Hammond, Paula T
Date Issued
January 2014
Journal
Biomaterials
Publisher
Elsevier
Citation
Morton, Stephen W.; Zhao, Xiaoyong; Quadir, Mohiuddin A. and Hammond, Paula T. “FRET-Enabled Biological Characterization of Polymeric Micelles.” Biomaterials 35, 11 (April 2014): 3489–3496 © 2014 Elsevier Ltd
Version
Author's final manuscript
Abstract
Translation of micelles from the laboratory to the clinic is limited by a poor understanding of their in vivo fate following administration. In this paper, we establish a robust approach to real-time monitoring of the in vivo stability of micelles using Förster Resonance Energy Transfer (FRET). This characterization method allows for exquisite insight into the fate of micellar constituents, affording the capabilities to rapidly and efficiently evaluate a library of synthetically derived micellar systems as new therapeutic platforms in vivo. FRET-enabled biological characterization further holds potential to tailor material systems being uniquely investigated across the delivery community towards the next generation of stable therapeutics for disease management.
MIT Department
Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.biomaterials.2014.01.027
