Log-domain circuit models of chemical reactions
Name
Mandal-2009-Log-domain circuit models of chemical reactions.pdf
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702 KB
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Checksum (MD5)
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Author(s)
Mandal, Soumyajit
Sarpeshkar, Rahul
Date Issued
June 2009
Journal
IEEE International Symposium on Circuits and Systems, 2009. ISCAS 2009
Publisher
Institute of Electrical and Electronics Engineers
Citation
Mandal, S., and R. Sarpeshkar. “Log-domain circuit models of chemical reactions.” Circuits and Systems, 2009. ISCAS 2009. IEEE International Symposium on. 2009. 2697-2700. ©2009 IEEE.
Version
Final published version
Abstract
We exploit the detailed similarities between electronics and chemistry to develop efficient, scalable bipolar or subthreshold log-domain circuits that are dynamically equivalent to networks of chemical reactions. Our circuits can be used for transient and steady-state simulations, parameter estimations and sensitivity analyses of large-scale biochemical networks. They allow the topology, rate constants, inputs, outputs and initial conditions of the reaction network to be programmed. When reactants are present in low concentrations, random fluctuations in reaction rates become significant; we can also model such stochastic effects. We present experimental results from a proof-of-concept chip implemented in 0.18 mum CMOS technology.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1109/ISCAS.2009.5118358
