Enzyme‐Triggered Intestine‐Specific Targeting Adhesive Platform for Universal Oral Drug Delivery
Name
Adv Healthcare Materials - 2023 - Li - Enzyme‐Triggered Intestine‐Specific Targeting Adhesive Platform for Universal Oral.pdf
Description
Published version
Size
3.97 MB
Format
Adobe PDF
Checksum (MD5)
5a0f1538c4a174eeafa1e895fd61b0ba
Author(s)
Li, Ying
Lee, Jung Seung
Kirtane, Ameya R.
Li, Mengyuan
Coffey, Charles William
Hess, Kaitlyn
Lopes, Aaron
Collins, Joy
Tamang, Siddartha
Ishida, Keiko
Date Issued
October 2023
Journal
Advanced Healthcare Materials
Publisher
Wiley
Citation
Y. Li, J. S. Lee, A. R. Kirtane, M. Li, C. W. Coffey III, K. Hess, A. Lopes, J. Collins, S. Tamang, K. Ishida, A. Hayward, J. Wainer, A. J. Wentworth, G. Traverso, Enzyme-Triggered Intestine-Specific Targeting Adhesive Platform for Universal Oral Drug Delivery. Adv. Healthcare Mater. 2023, 12, 2301033.
Version
Final published version
Abstract
Patient adherence to chronic therapies can be suboptimal, leading to poor therapeutic outcomes. Dosage forms that enable reduction in dosing frequency stand to improve patient adherence. Variation in gastrointestinal transit time, inter-individual differences in gastrointestinal physiology and differences in physicochemical properties of drugs represent challenges to the development of such systems. To this end, a small intestine-targeted drug delivery system is developed, where prolonged gastrointestinal retention and sustained release are achieved through tissue adhesion of drug pills mediated by an essential intestinal enzyme catalase. Here proof-of-concept pharmacokinetics is demonstrated in the swine model for two drugs, hydrophilic amoxicillin and hydrophobic levodopa. It is anticipated that this system can be applicable for many drugs with a diverse of physicochemical characteristics.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Division of Comparative Medicine
Massachusetts Institute of Technology. Department of Mechanical Engineering
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1002/adhm.202370169
