Synaptic Correlates of Binocular Convergence: Just a Coincidence?
Name
Scholl-2014-Synaptic correlates.pdf
Size
154 KB
Format
Adobe PDF
Checksum (MD5)
b3ef67103b7469f4dde2afbc5bee7afe
Author(s)
Scholl, Benjamin
Banerjee, Abhishek
Date Issued
July 2014
Journal
Journal of Neuroscience
Publisher
Society for Neuroscience
Citation
Scholl, B., and A. Banerjee. “Synaptic Correlates of Binocular Convergence: Just a Coincidence?” Journal of Neuroscience 34, no. 27 (July 2, 2014): 8931–8933.
Version
Final published version
Abstract
A longstanding goal in neuroscience is to identify and understand synaptic mechanisms underlying the formation of neural circuits that perform sensory computations. Maturation of these circuits proceeds through developmental milestones like the critical period (CP), a time when sensory systems are patterned by afferent sensory activity. In primary visual cortex (V1), dramatic changes occur in the anatomical and functional organization of ocular preference during the CP when retinal inputs converge and compete (Katz and Crowley, 2002; Espinosa and Stryker, 2012). In V1 of mice and other mammals, neurons in the binocular zone (Fig. 1) shift preference toward the ipsilateral eye if the contralateral eye is occluded during the CP (Gordon and Stryker, 1996). Despite extensive exploration of experience-dependent mechanisms in mouse V1, the specific nature of synaptic competition shaping the formation of ocular preference in individual target neurons has remained unknown. Recently, Chen and colleagues (2014) shed light on this question by demonstrating that strong coincidence of synaptic inputs from the two eyes is restricted to the CP. Their work suggests that temporal correlations of synaptic inputs between the two eyes, accompanied by an enhancement of GABAergic transmission, are essential features of the CP (Chen et al., 2014).
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1523/jneurosci.1598-14.2014
