Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities
Name
nihms-1836383.pdf
Description
Accepted version
Size
780.97 KB
Format
Adobe PDF
Checksum (MD5)
63e470d30d40fa4b8b3e8d5449d66998
Author(s)
Shi, Diana D
Guo, Jimmy A
Hoffman, Hannah I
Su, Jennifer
Mino-Kenudson, Mari
Barth, Jaimie L
Schenkel, Jason M
Loeffler, Jay S
Shih, Helen A
Hong, Theodore S
Date Issued
2022
Journal
Lancet Oncology
Publisher
Elsevier BV
Citation
Shi, Diana D, Guo, Jimmy A, Hoffman, Hannah I, Su, Jennifer, Mino-Kenudson, Mari et al. 2022. "Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities." Lancet Oncology, 23 (2).
Version
Author's final manuscript
Abstract
With increasing attention on the essential roles of the tumour microenvironment in recent years, the nervous system has emerged as a novel and crucial facilitator of cancer growth. In this Review, we describe the foundational, translational, and clinical advances illustrating how nerves contribute to tumour proliferation, stress adaptation, immunomodulation, metastasis, electrical hyperactivity and seizures, and neuropathic pain. Collectively, this expanding knowledge base reveals multiple therapeutic avenues for cancer neuroscience that warrant further exploration in clinical studies. We discuss the available clinical data, including ongoing trials investigating novel agents targeting the tumour-nerve axis, and the therapeutic potential for repurposing existing neuroactive drugs as an anti-cancer approach, particularly in combination with established treatment regimens. Lastly, we discuss the clinical challenges of these treatment strategies and highlight unanswered questions and future directions in the burgeoning field of cancer neuroscience.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Harvard University--MIT Division of Health Sciences and Technology
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/S1470-2045(21)00596-9
