What is memory? The present state of the engram
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document.pdf
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1.53 MB
Format
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Author(s)
Poo, Mu-ming
Bonhoeffer, Tobias
Martin, Kelsey C.
Tsien, Richard W.
Fishell, Gord
Mullins, Caitlin
Gonçalves, J. Tiago
Shtrahman, Matthew
Johnston, Stephen T.
Gage, Fred H.
Date Issued
May 2016
Journal
BMC Biology
Publisher
Biomed Central Ltd.
Citation
Poo, Mu-ming et al. “What Is Memory? The Present State of the Engram.” BMC Biology 14, 1 (May 2016) © 2016 Poo et al
Version
Final published version
Abstract
The mechanism of memory remains one of the great unsolved problems of biology. Grappling with the question more than a hundred years ago, the German zoologist Richard Semon formulated the concept of the engram, lasting connections in the brain that result from simultaneous "excitations", whose precise physical nature and consequences were out of reach of the biology of his day. Neuroscientists now have the knowledge and tools to tackle this question, however, and this Forum brings together leading contemporary views on the mechanisms of memory and what the engram means today.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1186/S12915-016-0261-6
