A Universal Approximation for Conductance Blockade in Thin Nanopore Membranes
Name
2312.11278v1.pdf
Description
Accepted version
Size
4.39 MB
Format
Adobe PDF
Checksum (MD5)
2c7ec26bef9ffaadb1d89f027e070f7c
Author(s)
Shah, Arjav
Pathak, Shakul
Li, Kun
Garaj, Slaven
Bazant, Martin Z
Gupta, Ankur
Doyle, Patrick S
Date Issued
2024
Journal
Nano Letters
Publisher
American Chemical Society
Citation
Cite this: Nano Lett. 2024, 24, 16, 4766–4773
Version
Author's final manuscript
Abstract
Nanopore-based sensing platforms have transformed single-molecule detection and analysis. The foundation of nanopore translocation experiments lies in conductance measurements, yet existing models, which are largely phenomenological, are inaccurate in critical experimental conditions such as thin and tightly fitting pores. Of the two components of the conductance blockade, channel and access resistance, the access resistance is poorly modeled. We present a comprehensive investigation of the access resistance and associated conductance blockade in thin nanopore membranes. By combining a first-principles approach, multiscale modeling, and experimental validation, we propose a unified theoretical modeling framework. The analytical model derived as a result surpasses current approaches across a broad parameter range. Beyond advancing our theoretical understanding, our framework's versatility enables analyte size inference and predictive insights into conductance blockade behavior. Our results will facilitate the design and optimization of nanopore devices for diverse applications, including nanopore base calling and data storage.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Singapore-MIT Alliance in Research and Technology (SMART)
Massachusetts Institute of Technology. Department of Mathematics
Terms of Use
Creative Commons Attribution-Noncommercial-ShareAlike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1021/acs.nanolett.3c04997
