Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep
Name
Dort-2015-Optogenetic activati.pdf
Size
1.67 MB
Format
Adobe PDF
Checksum (MD5)
a64e2d8e3a81a9fb1cfdb5fc9b7f6629
Author(s)
Zheng, Shu
Goldblum, Rebecca R.
Gelwan, Noah A.
Ramos, Daniel M.
Nolan, Michael A.
Wang, Karen
Weng, Feng-Ju
Lin, Yingxi
Wilson, Matthew A.
Brown, Emery N.
Date Issued
January 2015
Journal
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences (U.S.)
Citation
Van Dort, Christa J., Daniel P. Zachs, Jonathan D. Kenny, Shu Zheng, Rebecca R. Goldblum, Noah A. Gelwan, Daniel M. Ramos, et al. “Optogenetic Activation of Cholinergic Neurons in the PPT or LDT Induces REM Sleep.” Proc Natl Acad Sci USA 112, no. 2 (December 29, 2014): 584–589.
Version
Final published version
Abstract
Rapid eye movement (REM) sleep is an important component of the natural sleep/wake cycle, yet the mechanisms that regulate REM sleep remain incompletely understood. Cholinergic neurons in the mesopontine tegmentum have been implicated in REM sleep regulation, but lesions of this area have had varying effects on REM sleep. Therefore, this study aimed to clarify the role of cholinergic neurons in the pedunculopontine tegmentum (PPT) and laterodorsal tegmentum (LDT) in REM sleep generation. Selective optogenetic activation of cholinergic neurons in the PPT or LDT during non-REM (NREM) sleep increased the number of REM sleep episodes and did not change REM sleep episode duration. Activation of cholinergic neurons in the PPT or LDT during NREM sleep was sufficient to induce REM sleep.
MIT Department
Institute for Medical Engineering and Science
Harvard University--MIT Division of Health Sciences and Technology
Lincoln Laboratory
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research at MIT
Picower Institute for Learning and Memory
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1073/pnas.1423136112
