Vertebrate Evolution Conserves Hindbrain Circuits despite Diverse Feeding and Breathing Modes
Name
ENEURO.0435-20.2021.full.pdf
Description
Published version
Size
1.6 MB
Format
Adobe PDF
Checksum (MD5)
2b008c6faaba32cf204c4600c3bf86da
Author(s)
Li, Shun
Wang, Fan
Date Issued
March 2021
Journal
eneuro
Publisher
Society for Neuroscience
Citation
Shun Li, Fan Wang, eNeuro 11 March 2021, 8 (2) ENEURO.0435-20.2021.
Version
Final published version
Abstract
Feeding and breathing are two functions vital to the survival of all vertebrate species. Throughout the evolution, vertebrates living in different environments have evolved drastically different modes of feeding and breathing through using diversified orofacial and pharyngeal (oropharyngeal) muscles. The oropharyngeal structures are controlled by hindbrain neural circuits. The developing hindbrain shares strikingly conserved organizations and gene expression patterns across vertebrates, thus begs the question of how a highly conserved hindbrain generates circuits subserving diverse feeding/breathing patterns. In this review, we summarize major modes of feeding and breathing and principles underlying their coordination in many vertebrate species. We provide a hypothesis for the existence of a common hindbrain circuit at the phylotypic embryonic stage controlling oropharyngeal movements that is shared across vertebrate species; and reconfiguration and repurposing of this conserved circuit give rise to more complex behaviors in adult higher vertebrates.
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1523/ENEURO.0435-20.2021
