Devices for drug delivery in the gastrointestinal tract: A review of systems physically interacting with the mucosa for enhanced delivery
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ADDR_Final.pdf
Description
Accepted version
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697.74 KB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Byrne, James
Huang, Hen-Wei
McRae, James C
Babaee, Sahab
Soltani, Amin
Becker, Sarah L
Traverso, Giovanni
Date Issued
2021
Journal
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Citation
Byrne, James, Huang, Hen-Wei, McRae, James C, Babaee, Sahab, Soltani, Amin et al. 2021. "Devices for drug delivery in the gastrointestinal tract: A review of systems physically interacting with the mucosa for enhanced delivery." Advanced Drug Delivery Reviews, 177.
Version
Author's final manuscript
Abstract
The delivery of macromolecules via the gastrointestinal (GI) tract remains a significant challenge. A variety of technologies using physical modes of drug delivery have been developed and investigated to overcome the epithelial cell layer of the GI tract for local and systemic delivery. These technologies include direct injection, jetting, ultrasound, and iontophoresis, which have been largely adapted from transdermal drug delivery. Direct injection of agents using needles through endoscopy has been used clinically for over a century. Jetting, a needle-less method of drug delivery where a high-speed stream of fluid medication penetrates tissue, has been evaluated pre-clinically for delivery of agents into the buccal mucosa. Ultrasound has been shown to be beneficial in enhancing delivery of macromolecules, including nucleic acids, in pre-clinical animal models. The application of an electric field gradient to drive drugs into tissues through the technique of iontophoresis has been shown to deliver highly toxic chemotherapies into GI tissues. Here in, we provide an in-depth overview of these physical modes of drug delivery in the GI tract and their clinical and preclinical uses.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/J.ADDR.2021.113926
