Aneuploidy Drives Genomic Instability in Yeast
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Amon_Aneuploidy drives.pdf
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Author(s)
Sheltzer, Jason Meyer
Blank, Heidi Marie
Pfau, Sarah Jeanne
Tange, Yoshie
George, Benson M.
Humpton, Timothy J.
Brito, Ilana Lauren
Hiraoka, Yasushi
Niwa, Osami
Amon, Angelika B
Date Issued
August 2011
Journal
Science
Publisher
American Association for the Advancement of Science
Citation
Sheltzer, J. M., H. M. Blank, S. J. Pfau, Y. Tange, B. M. George, T. J. Humpton, I. L. Brito, Y. Hiraoka, O. Niwa, and A. Amon. “Aneuploidy Drives Genomic Instability in Yeast.” Science 333, no. 6045 (August 18, 2011): 1026-1030.
Version
Author's final manuscript
Abstract
Aneuploidy decreases cellular fitness, yet it is also associated with cancer, a disease of enhanced proliferative capacity. To investigate one mechanism by which aneuploidy could contribute to tumorigenesis, we examined the effects of aneuploidy on genomic stability. We analyzed 13 budding yeast strains that carry extra copies of single chromosomes and found that all aneuploid strains exhibited one or more forms of genomic instability. Most strains displayed increased chromosome loss and mitotic recombination, as well as defective DNA damage repair. Aneuploid fission yeast strains also exhibited defects in mitotic recombination. Aneuploidy-induced genomic instability could facilitate the development of genetic alterations that drive malignant growth in cancer.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1126/science.1206412
