Alzheimer’s Amyloid Hypothesis and Antibody Therapy: Melting Glaciers?
Name
ijms-25-03892-v3.pdf
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5.1 MB
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Adobe PDF
Checksum (MD5)
0a483731a551b20c69b813efc16ba34a
Author(s)
Høilund-Carlsen, Poul F.
Alavi, Abass
Castellani, Rudolph J.
Neve, Rachael L.
Perry, George
Revheim, Mona-Elisabeth
Barrio, Jorge R.
Date Issued
March 31, 2024
Journal
International Journal of Molecular Sciecnes
Publisher
MDPI AG
Citation
Høilund-Carlsen PF, Alavi A, Castellani RJ, Neve RL, Perry G, Revheim M-E, Barrio JR. Alzheimer’s Amyloid Hypothesis and Antibody Therapy: Melting Glaciers? International Journal of Molecular Sciences. 2024; 25(7):3892.
Version
Final published version
Abstract
The amyloid cascade hypothesis for Alzheimer’s disease is still alive, although heavily challenged. Effective anti-amyloid immunotherapy would confirm the hypothesis’ claim that the protein amyloid-beta is the cause of the disease. Two antibodies, aducanumab and lecanemab, have been approved by the U.S. Food and Drug Administration, while a third, donanemab, is under review. The main argument for the FDA approvals is a presumed therapy-induced removal of cerebral amyloid deposits. Lecanemab and donanemab are also thought to cause some statistical delay in the determination of cognitive decline. However, clinical efficacy that is less than with conventional treatment, selection of amyloid-positive trial patients with non-specific amyloid-PET imaging, and uncertain therapy-induced removal of cerebral amyloids in clinical trials cast doubt on this anti-Alzheimer’s antibody therapy and hence on the amyloid hypothesis, calling for a more thorough investigation of the negative impact of this type of therapy on the brain.
Subjects
Inorganic Chemistry
Organic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Catalysis
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.3390/ijms25073892
