Critical Role of Smad and AP-1 Complexes in TGF-β-Dependent Apoptosis
Name
TSWJ.2001.537360.pdf
Size
36.63 KB
Format
Adobe PDF
Checksum (MD5)
ecff2ec13b0dd9265e6296d63768e568
Download all files submitted through automated deposit
Author(s)
Yamamura, Yasuko
Hua, Xianxin
Bergelson, Svetlana
Lodish, Harvey F
Date Issued
2001
Journal
The Scientific World JOURNAL
Publisher
Hindawi Publishing Corporation
Citation
Yamamura, Yasuko et al. “Critical Role of Smad and AP-1 Complexes in TGF-Β-Dependent Apoptosis.” The Scientific World JOURNAL 1 (2001): 96–96.
Version
Final published version
Abstract
Transforming growth factor-β1 (TGF-β1) induces not only cell growth inhibition but also apoptosis in hepatocytes, myeloid cells, and epithelial cells. Smad complexes (Smad2-Smad4 and Smad3-Smad4) are identified as key signaling molecules which
transmit TGF-β1 signal for growth inhibition from the TGF-β receptors to the nucleus (1, 2). However, their roles are unclear in the induction of apoptosis. Our results show here that both Smad and AP-1 complexes play a critical role in TGF-β1 signaling for apoptosis.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1100/tsw.2001.201
