Clotting Mimicry from Robust Hemostatic Bandages Based on Self-Assembling Peptides
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Hammond_Clotting mimicry.pdf
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Author(s)
Tschabrunn, Cory M.
Mehta, Manav
Perez-Cuevas, Monica B.
Zhang, Shuguang
Hsu, Bryan Boen
Conway, William E.
Hammond, Paula T
Date Issued
August 2015
Journal
ACS Nano
Publisher
American Chemical Society (ACS)
Citation
Hsu, Bryan B., William Conway, Cory M. Tschabrunn, Manav Mehta, Monica B. Perez-Cuevas, Shuguang Zhang, and Paula T. Hammond. “Clotting Mimicry from Robust Hemostatic Bandages Based on Self-Assembling Peptides.” ACS Nano 9, no. 9 (September 22, 2015): 9394–9406. © 2015 American Chemical Society
Version
Final published version
Abstract
Uncontrolled bleeding from traumatic wounds is a major factor in deaths resulting from military conflict, accidents, disasters and crime. Self-assembling peptide nanofibers have shown superior hemostatic activity, and herein, we elucidate their mechanism by visualizing the formation of nanofiber-based clots that aggregate blood components with a similar morphology to fibrin-based clots. Furthermore, to enhance its direct application to a wound, we developed layer-by-layer assembled thin film coatings onto common materials used for wound dressings—gauze and gelatin sponges. We find these nanofibers elute upon hydration under physiological conditions and generate nanofiber-based clots with blood. After exposure to a range of harsh temperature conditions (−80 to 60 °C) for a week and even 5 months at 60 °C, these hemostatic bandages remain capable of releasing active nanofibers. In addition, the application of these nanofiber-based films from gauze bandages was found to accelerate hemostasis in porcine skin wounds as compared to plain gauze. The thermal robustness, in combination with the self-assembling peptide’s potent hemostatic activity, biocompatibility, biodegradability, and low cost of production, makes this a promising approach for a cheap yet effective hemostatic bandage.
MIT Department
Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies
Massachusetts Institute of Technology. Center for Bits and Atoms
Massachusetts Institute of Technology. Department of Architecture
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Chemistry
Massachusetts Institute of Technology. Department of Physics
Massachusetts Institute of Technology. Media Laboratory
Program in Media Arts and Sciences (Massachusetts Institute of Technology)
Koch Institute for Integrative Cancer Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/acsnano.5b02374
