Balancing repair and tolerance of DNA damage caused by alkylating agents
Name
Samson_Balancing repair.pdf
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1.89 MB
Format
Adobe PDF
Checksum (MD5)
3eeb82f75f723ed2b82556f4537371a3
Author(s)
Fu, Dragony
Calvo, Jennifer A.
Samson, Leona D
Date Issued
January 2012
Journal
Nature Reviews Cancer
Publisher
Nature Publishing Group
Citation
Fu, Dragony, Jennifer A. Calvo, and Leona D. Samson. “Balancing Repair and Tolerance of DNA Damage Caused by Alkylating Agents.” Nature Reviews Cancer (January 12, 2012).
Version
Author's final manuscript
Abstract
Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict cytotoxic DNA damage as their main mode of action, in addition to collateral mutagenic damage. Numerous cellular pathways, including direct DNA damage reversal, base excision repair (BER) and mismatch repair (MMR), respond to alkylation damage to defend against alkylation-induced cell death or mutation. However, maintaining a proper balance of activity both within and between these pathways is crucial for a favourable response of an organism to alkylating agents. Furthermore, the response of an individual to alkylating agents can vary considerably from tissue to tissue and from person to person, pointing to genetic and epigenetic mechanisms that modulate alkylating agent toxicity.
MIT Department
Massachusetts Institute of Technology. Center for Environmental Health Sciences
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1038/nrc3185
