A wireless-compatible CMOS-based celluar sensor
Name
Anwar-2009-A wireless-compatible CMOS-based celluar sensor.pdf
Size
765.86 KB
Format
Adobe PDF
Checksum (MD5)
1f1f6cfc3c93aa6e23dcfe99fb13e281
Author(s)
Matsudaira, Paul T.
Anwar, Mekhail
Date Issued
June 2009
Journal
Solid-State Sensors, Actuators and Microsystems Conference. TRANSDUCERS
Publisher
Institute of Electrical and Electronics Engineers
Citation
M. Anwar and P. Matsudaira, “Wireless-compatible CMOS-based celluar sensor,” in Solid-State Sensors, Actuators and Microsystems Conference, 2009. TRANSDUCERS 2009. International, 2009, 936-938, 10.1109/SENSOR.© 2009, IEEE
Version
Final published version
Abstract
Biosensors have a need to accurately detect and quantify a biological target within a complex medium, such as serum. Cells are uniquely qualified to accomplish this, but cannot communicate with the outside world. We demonstrate a synergistic fusion between a genetically engineered cell line and a wireless-compatible CMOS sensor leveraging the cells innate ability to specifically bind, amplify and transduce the signal with electronics that are capable transforming this cellular signal into an electronic one. We demonstrate the detection of TNF-alpha (TNFalpha) within serum without washing. Since cells are real-time transducers of binding events, real-time monitoring of biological agents and reactions are possible.
Description
The title as published reads "celluar sensor" but should be "cellular sensor."
Subjects
CMOS
Imaging
Array
Cell-based
Biosensor
Luciferase
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Whitehead Institute for Biomedical Research
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1109/SENSOR.2009.5285970
