Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune function
Name
Genes Dev.-2021-Akay-180-98.pdf
Description
Published version
Size
820.39 KB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Akay, Leyla Anne
Effenberger, Audrey H.
Tsai, Li-Huei
Date Issued
February 2021
Journal
Genes & Development
Publisher
Cold Spring Harbor Laboratory
Citation
Akay, Leyla Anne et al. "Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune function." Genes & Development 35, 3-4 (February 2021): 180-198. © 2021 Akay et al
Version
Final published version
Abstract
Oligodendrocyte precursor cells (OPCs) are not merely a transitory progenitor cell type, but rather a distinct and heterogeneous population of glia with various functions in the developing and adult central nervous system. In this review, we discuss the fate and function of OPCs in the brain beyond their contribution to myelination. OPCs are electrically sensitive, form synapses with neurons, support blood-brain barrier integrity, and mediate neuroinflammation. We explore how sex and age may influence OPC activity, and we review how OPC dysfunction may play a primary role in numerous neurological and neuropsychiatric diseases. Finally, we highlight areas of future research.
MIT Department
Picower Institute for Learning and Memory
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution NonCommercial License 4.0
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1101/gad.344218.120
