Casting inorganic structures with DNA molds
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Bathe_Casting inorganic.pdf
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1.24 MB
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Checksum (MD5)
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Author(s)
Sun, Wei
Boulais, Etienne
Hakobyan, Yera
Wang, Wei Li
Guan, Amy
Bathe, Mark
Yin, Peng
Date Issued
October 2014
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Sun, W., E. Boulais, Y. Hakobyan, W. L. Wang, A. Guan, M. Bathe, and P. Yin. “Casting Inorganic Structures with DNA Molds.” Science 346, no. 6210 (October 9, 2014): 1258361–1258361.
Version
Author's final manuscript
Abstract
We report a general strategy for designing and synthesizing inorganic nanostructures with arbitrarily prescribed three-dimensional shapes. Computationally designed DNA strands self-assemble into a stiff “nanomold” that contains a user-specified three-dimensional cavity and encloses a nucleating gold “seed.” Under mild conditions, this seed grows into a larger cast structure that fills and thus replicates the cavity. We synthesized a variety of nanoparticles with 3-nanometer resolution: three distinct silver cuboids with three independently tunable dimensions, silver and gold nanoparticles with diverse cross sections, and composite structures with homo- and heterogeneous components. The designer equilateral silver triangular and spherical nanoparticles exhibited plasmonic properties consistent with electromagnetism-based simulations. Our framework is generalizable to more complex geometries and diverse inorganic materials, offering a range of applications in biosensing, photonics, and nanoelectronics.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1126/science.1258361
