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An Open Resource for Non-human Primate Optogenetics
Name
nihms-1670678.pdf
Description
Accepted version
Size
1.97 MB
Format
Adobe PDF
Checksum (MD5)
844f8754176b3f1db9778ec2e187e0df
Date Issued
2020
Journal
Neuron
Publisher
Elsevier BV
Citation
2020. "An Open Resource for Non-human Primate Optogenetics." Neuron, 108 (6).
Version
Author's final manuscript
Abstract
© 2020 Elsevier Inc. Optogenetics has revolutionized neuroscience in small laboratory animals, but its effect on animal models more closely related to humans, such as non-human primates (NHPs), has been mixed. To make evidence-based decisions in primate optogenetics, the scientific community would benefit from a centralized database listing all attempts, successful and unsuccessful, of using optogenetics in the primate brain. We contacted members of the community to ask for their contributions to an open science initiative. As of this writing, 45 laboratories around the world contributed more than 1,000 injection experiments, including precise details regarding their methods and outcomes. Of those entries, more than half had not been published. The resource is free for everyone to consult and contribute to on the Open Science Framework website. Here we review some of the insights from this initial release of the database and discuss methodological considerations to improve the success of optogenetic experiments in NHPs.
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
10.1016/J.NEURON.2020.09.027
