Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast agents
Name
e2102340118.full.pdf
Description
Published version
Size
1.47 MB
Format
Adobe PDF
Checksum (MD5)
27fd8c60bb54fc803378650b705a750e
Author(s)
Wei, He
Wiśniowska, Agata
Fan, Jingxuan
Harvey, Peter
Li, Yuanyuan
Wu, Victoria
Hansen, Eric C
Zhang, Juanye
Kaul, Michael G
Frey, Abigail M
Date Issued
2021
Journal
Proceedings of the National Academy of Sciences of the United States of America
Publisher
Proceedings of the National Academy of Sciences
Citation
Wei, He, Wiśniowska, Agata, Fan, Jingxuan, Harvey, Peter, Li, Yuanyuan et al. 2021. "Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast agents." Proceedings of the National Academy of Sciences of the United States of America, 118 (42).
Version
Final published version
Abstract
>Magnetic nanoparticles are robust contrast agents for MRI and often produce particularly strong signal changes per particle. Leveraging these effects to probe cellular- and molecular-level phenomena in tissue can, however, be hindered by the large sizes of typical nanoparticle contrast agents. To address this limitation, we introduce single-nanometer iron oxide (SNIO) particles that exhibit superparamagnetic properties in conjunction with hydrodynamic diameters comparable to small, highly diffusible imaging agents. These particles efficiently brighten the signal in T1-weighted MRI, producing per-molecule longitudinal relaxation enhancements over 10 times greater than conventional gadolinium-based contrast agents. We show that SNIOs permeate biological tissue effectively following injection into brain parenchyma or cerebrospinal fluid. We also demonstrate that SNIOs readily enter the brain following ultrasound-induced blood–brain barrier disruption, emulating the performance of a gadolinium agent and providing a basis for future biomedical applications. These results thus demonstrate a platform for MRI probe development that combines advantages of small-molecule imaging agents with the potency of nanoscale materials.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Chemistry
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DOI of Published Version
https://doi.org/10.1073/PNAS.2102340118
