Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation
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Author(s)
Karwacz, Katarzyna
Miraldi, Emily R
Pokrovskii, Maria
Madi, Asaf
Yosef, Nir
Wortman, Ivo
Chen, Xi
Watters, Aaron
Carriero, Nicholas
Awasthi, Amit
Date Issued
February 2017
Journal
Nature Immunology
Publisher
Nature Publishing Group
Citation
Karwacz, Katarzyna et al. “Critical Role of IRF1 and BATF in Forming Chromatin Landscape During Type 1 Regulatory Cell Differentiation.” Nature Immunology 18, 4 (February 2017): 412–421 © 2017 Nature America Inc, part of Springer Nature
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Author's final manuscript
Abstract
Type 1 regulatory T cells (Tr1 cells) are induced by interleukin-27 (IL-27) and have critical roles in the control of autoimmunity and resolution of inflammation. We found that the transcription factors IRF1 and BATF were induced early on after treatment with IL-27 and were required for the differentiation and function of Tr1 cells in vitro and in vivo. Epigenetic and transcriptional analyses revealed that both transcription factors influenced chromatin accessibility and expression of the genes required for Tr1 cell function. IRF1 and BATF deficiencies uniquely altered the chromatin landscape, suggesting that these factors serve a pioneering function during Tr1 cell differentiation.
MIT Department
Broad Institute of MIT and Harvard
Massachusetts Institute of Technology. Department of Biology
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DOI of Published Version
https://doi.org/10.1038/NI.3683
