Identification of the Active Principle Conferring Anti-Inflammatory and Antinociceptive Properties in Bamboo Plant
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molecules-26-03054-v2.pdf
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2.29 MB
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Checksum (MD5)
346e072d5715c70e6431b88cdd611648
Author(s)
Araujo Sousa, Bruna
Nascimento Silva, Osmar
Farias Porto, William
Lima Rocha, Thales
Paulino Silva, Luciano
Ferreira Leal, Ana Paula
Buccini, Danieli Fernanda
Oluwagbamigbe Fajemiroye, James
de Araujo Caldas, Ruy
Franco, Octávio Luiz
Date Issued
May 2021
Journal
Molecules
Publisher
Multidisciplinary Digital Publishing Institute
Citation
Molecules 26 (10): 3054 (2021)
Version
Final published version
Abstract
Early plants began colonizing earth about 450 million years ago. During the process of coevolution, their metabolic cellular pathways produced a myriad of natural chemicals, many of which remain uncharacterized biologically. Popular preparations containing some of these molecules have been used medicinally for thousands of years. In Brazilian folk medicine, plant extracts from the bamboo plant Guadua paniculata Munro have been used for the treatment of infections and pain. However, the chemical basis of these therapeutic effects has not yet been identified. Here, we performed protein biochemistry and downstream pharmacological assays to determine the mechanisms underlying the anti-inflammatory and antinociceptive effects of an aqueous extract of the G. paniculata rhizome, which we termed AqGP. The anti-inflammatory and antinociceptive effects of AqGP were assessed in mice. We identified and purified a protein (AgGP), with an amino acid sequence similar to that of thaumatins (~20 kDa), capable of repressing inflammation through downregulation of neutrophil recruitment and of decreasing hyperalgesia in mice. In conclusion, we have identified the molecule and the molecular mechanism responsible for the anti-inflammatory and antinociceptive properties of a plant commonly used in Brazilian folk medicine.
MIT Department
Massachusetts Institute of Technology. Research Laboratory of Electronics
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Center for Microbiome Informatics and Therapeutics
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.3390/molecules26103054
