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A Blood-Resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects
Name
nihms571842.pdf
Description
Accepted version
Size
832.66 KB
Format
Adobe PDF
Checksum (MD5)
abafe12830d38e5bc29eefb935ac5b5f
Author(s)
Lang, N
Pereira, MJ
Lee, Y
Friehs, I
Vasilyev, NV
Feins, EN
Ablasser, K
O'Cearbhaill, ED
Xu, C
Fabozzo, A
Date Issued
2014
Journal
Science Translational Medicine
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Lang, N., et al. "A Blood-Resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects." Science Translational Medicine 6 218 (2014).
Version
Author's final manuscript
Abstract
Currently, there are no clinically approved surgical glues that are nontoxic, bind strongly to tissue, and work well withinwet and highly dynamic environments within the body. This is especially relevant tominimally invasive surgery that is increasingly performed to reduce postoperative complications, recovery times, and patient discomfort. We describe the engineering of a bioinspired elastic and biocompatible hydrophobic light-activated adhesive (HLAA) that achieves a strong level of adhesion to wet tissue and is not compromised by preexposure to blood. The HLAA provided an on-demand hemostatic seal, within seconds of light application, when applied to high-pressure large blood vessels and cardiac wall defects in pigs. HLAA-coated patches attached to the interventricular septum in a beating porcine heart and resisted supraphysiologic pressures by remaining attached for 24 hours, which is relevant to intracardiac interventions in humans. The HLAA could be used for many cardiovascular and surgical applications, with immediate application in repair of vascular defects and surgical hemostasis.
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
10.1126/SCITRANSLMED.3006557
