Increasing The Odds Of Hit Iidentification By Screening Against Receptor Homologs
Name
MEBCS016.pdf
Size
120.36 KB
Format
Adobe PDF
Checksum (MD5)
e7059360471397f8339d49ccd28635f9
Author(s)
Chen, Yuzong
Cai, Congzhong
Li, Zerong
Han, Lianyi
Wang, Jifeng
Date Issued
January 2003
Series/Report no.
Molecular Engineering of Biological and Chemical Systems (MEBCS);
Abstract
Increasing the odds of hit identification in screening is of significance for drug discovery. The odds for finding a hit are closely related either to the diversity of libraries or to the availability of focused libraries. There are no truly diverse libraries and it is difficult to design focused libraries without sufficient information. Hence it is helpful to consider alternative approaches that can enhance the odds using existing libraries. Multiple members of a protein family have been considered collectively in inhibitor design, on the basis of the correlation between protein families and ligands derived from specific compound classes. Such a correlation has been exploited in various drug discovery studies and a general receptor-homolog-based screening scheme may be devised. The feasibility of such a scheme in enhancing the odds of hit identification is discussed.
Subjects
homology
inhibitors
screening
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