Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates
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Anderson_Combinatorial hydrogel.pdf
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Author(s)
Hollister-Locke, Jennifer
Bochenek, Matthew A
Dholakia, Nimit
Cohen, Josh
Siniakowicz, Karolina
Qi, Meirigeng
McGarrigle, James
Lyle, Stephen
Harlan, David M
Greiner, Dale L
Date Issued
January 2016
Journal
Nature Biotechnology
Publisher
Nature Publishing Group
Citation
Vegas, Arturo J; Veiseh, Omid; Doloff, Joshua C; Ma, Minglin; Tam, Hok Hei; Bratlie, Kaitlin; Li, Jie, et al. “Combinatorial Hydrogel Library Enables Identification of Materials That Mitigate the Foreign Body Response in Primates.” Nature Biotechnology 34, no. 3 (January 2016): 345–352. © 2016 Nature America, Inc
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Author's final manuscript
Abstract
The foreign body response is an immune-mediated reaction that can lead to the failure of implanted medical devices and discomfort for the recipient. There is a critical need for biomaterials that overcome this key challenge in the development of medical devices. Here we use a combinatorial approach for covalent chemical modification to generate a large library of variants of one of the most widely used hydrogel biomaterials, alginate. We evaluated the materials in vivo and identified three triazole-containing analogs that substantially reduce foreign body reactions in both rodents and, for at least 6 months, in non-human primates. The distribution of the triazole modification creates a unique hydrogel surface that inhibits recognition by macrophages and fibrous deposition. In addition to the utility of the compounds reported here, our approach may enable the discovery of other materials that mitigate the foreign body response.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Division of Comparative Medicine
Massachusetts Institute of Technology. Spectroscopy Laboratory
Koch Institute for Integrative Cancer Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1038/nbt.3462
