Heparin‐Coated Albumin Nanoparticles for Drug Combination in Targeting Inflamed Intestine
Name
nihms-1624869.pdf
Description
Accepted version
Size
853.95 KB
Format
Adobe PDF
Checksum (MD5)
d34088858b1405895d1b2c873f194bba
Author(s)
Zhang, Sufeng
Cho, Won Joon
Jin, Amy T
Kok, Lie Yun
Shi, Yunhua
Heller, David E
Lee, Young-Ah Lucy
Zhou, Yixuan
Xie, Xi
Korzenik, Joshua R
Date Issued
2020
Journal
Advanced Healthcare Materials
Publisher
Wiley
Citation
Zhang, Sufeng, Cho, Won Joon, Jin, Amy T, Kok, Lie Yun, Shi, Yunhua et al. 2020. "Heparin‐Coated Albumin Nanoparticles for Drug Combination in Targeting Inflamed Intestine." Advanced Healthcare Materials, 9 (16).
Version
Author's final manuscript
Abstract
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Targeting areas of inflammation offers potential therapeutic and diagnostic benefits by maximizing drug and imaging marker on-target effects while minimizing systemic exposure that can be associated with adverse side effects. This strategy is particularly beneficial in the management of inflammatory bowel disease (IBD). Here an inflammation-targeting (IT) approach based on heparin-coated human serum albumin nanoparticles (HEP-HSA NPs) that utilize the increased intestinal permeability and changes in electrostatic interaction at the site of intestinal inflammation is described. Using small-molecule and biologic drugs as a model for drug combination, the HEP-HSA NPs demonstrate the capacity to load both drugs simultaneously; the dual-drug loaded HEP-HSA NPs exhibit a higher anti-inflammatory effect than both of the single-drug loaded NPs in vitro and selectively bind to inflamed intestine after enema administration in vivo in a murine model of colitis. Importantly, analyses of the physicochemical characteristics and targeting capacities of these NPs indicate that HEP coating modulates NP binding to the inflamed intestine, providing a foundation for future IT-NP formulation development.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/ADHM.202000536
