Painting blood vessels and atherosclerotic plaques with an adhesive drug depot
Name
Kastrup-2012-Painting Blood Vessels and Atherosclerotic Plaques with an Adhesive Drug Depot.pdf
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1.35 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Kastrup, Christian
Nahrendorf, Matthias
Figueiredo, Jose Luiz
Lee, Haeshin
Kambhampati, Swetha
Lee, Timothy
Cho, Seung Woo
Gorbatov, Rostic
Iwamoto, Yoshiko
Dang, Tram T.
Date Issued
December 2012
Journal
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences (U.S.)
Citation
Kastrup, C. J., M. Nahrendorf, J. L. Figueiredo, H. Lee, S. Kambhampati, T. Lee, S.-W. Cho, et al. “Painting blood vessels and atherosclerotic plaques with an adhesive drug depot.” Proceedings of the National Academy of Sciences 109, no. 52 (December 26, 2012): 21444-21449.
Version
Final published version
Abstract
The treatment of diseased vasculature remains challenging, in part because of the difficulty in implanting drug-eluting devices without subjecting vessels to damaging mechanical forces. Implanting materials using adhesive forces could overcome this challenge, but materials have previously not been shown to durably adhere to intact endothelium under blood flow. Marine mussels secrete strong underwater adhesives that have been mimicked in synthetic systems. Here we develop a drug-eluting bioadhesive gel that can be locally and durably glued onto the inside surface of blood vessels. In a mouse model of atherosclerosis, inflamed plaques treated with steroid-eluting adhesive gels had reduced macrophage content and developed protective fibrous caps covering the plaque core. Treatment also lowered plasma cytokine levels and biomarkers of inflammation in the plaque. The drug-eluting devices developed here provide a general strategy for implanting therapeutics in the vasculature using adhesive forces and could potentially be used to stabilize rupture-prone plaques.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1073/pnas.1217972110
