Fast Recurrent Processing via Ventrolateral Prefrontal Cortex Is Needed by the Primate Ventral Stream for Robust Core Visual Object Recognition
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1-s2.0-S0896627320307595-main.pdf
Description
Published version
Size
4.04 MB
Format
Adobe PDF
Checksum (MD5)
17a74c63cc22d88ebbb91a25f8843999
Author(s)
Kar, Kohitij
DiCarlo, James J
Date Issued
2021
Journal
Neuron
Publisher
Elsevier BV
Version
Final published version
Abstract
© 2020 The Author(s) Distributed neural population spiking patterns in macaque inferior temporal (IT) cortex that support core object recognition require additional time to develop for specific, “late-solved” images. This suggests the necessity of recurrent processing in these computations. Which brain circuits are responsible for computing and transmitting these putative recurrent signals to IT? To test whether the ventrolateral prefrontal cortex (vlPFC) is a critical recurrent node in this system, here, we pharmacologically inactivated parts of vlPFC and simultaneously measured IT activity while monkeys performed object discrimination tasks. vlPFC inactivation deteriorated the quality of late-phase (>150 ms from image onset) IT population code and produced commensurate behavioral deficits for late-solved images. Finally, silencing vlPFC caused the monkeys’ IT activity and behavior to become more like those produced by feedforward-only ventral stream models. Together with prior work, these results implicate fast recurrent processing through vlPFC as critical to producing behaviorally sufficient object representations in IT.
MIT Department
McGovern Institute for Brain Research at MIT
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Center for Brains, Minds, and Machines
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/J.NEURON.2020.09.035
