A comparative genomics multitool for scientific discovery and conservation
Name
s41586-020-2876-6.pdf
Description
Published version
Size
5.14 MB
Format
Unknown
Checksum (MD5)
b70b9f8c3f369ab36fc674cd0e41774d
Author(s)
Genereux, DP
Serres, A
Armstrong, J
Johnson, J
Marinescu, VD
Muren, E
Juan, D
Bejerano, G
Casewell, NR
Chemnick, LG
Date Issued
November 12, 2020
Journal
Nature
Publisher
Springer Science and Business Media LLC
Version
Final published version
Abstract
© 2020, The Author(s). The Zoonomia Project is investigating the genomics of shared and specialized traits in eutherian mammals. Here we provide genome assemblies for 131 species, of which all but 9 are previously uncharacterized, and describe a whole-genome alignment of 240 species of considerable phylogenetic diversity, comprising representatives from more than 80% of mammalian families. We find that regions of reduced genetic diversity are more abundant in species at a high risk of extinction, discern signals of evolutionary selection at high resolution and provide insights from individual reference genomes. By prioritizing phylogenetic diversity and making data available quickly and without restriction, the Zoonomia Project aims to support biological discovery, medical research and the conservation of biodiversity.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/s41586-020-2876-6
