Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery
Name
Anderson_Bioinspired alkenyl.pdf
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645.14 KB
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Author(s)
DeRosa, Frank
Langer, Robert
Kauffman, Kevin John
McClellan, Rebecca L
Appel, Eric
Dorkin, Joseph Robert
Tibbitt, Mark W
Langer, Robert S
Anderson, Daniel Griffith
Fenton, Owen Shea
Date Issued
February 2016
Journal
Advanced Materials
Publisher
Wiley Blackwell
Citation
Fenton, Owen S. et al. “Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery.” Advanced Materials 28.15 (2016): 2939–2943.
Version
Author's final manuscript
Abstract
Thousands of human diseases could be treated by selectively controlling the expression of specific proteins in vivo. A new series of alkenyl amino alcohol (AAA) ionizable lipid nanoparticles (LNPs) capable of delivering human mRNA with unprecedented levels of in vivo efficacy is demonstrated. This study highlights the importance of utilizing synthesis tools in tandem with biological inspiration to understand and improve nucleic acid delivery in vivo.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Chemistry
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/adma.201505822
