Ten things you should know about transposable elements
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13059_2018_Article_1577.pdf
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543.76 KB
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Adobe PDF
Checksum (MD5)
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Author(s)
Bourque, Guillaume
Burns, Kathleen H
Gehring, Mary
Gorbunova, Vera
Seluanov, Andrei
Hammell, Molly
Imbeault, Michaël
Izsvák, Zsuzsanna
Levin, Henry L
Macfarlan, Todd S
Date Issued
November 2018
Journal
Genome Biology
Publisher
BioMed Central
Citation
Bourque, Guillaume et al. "Ten things you should know about transposable elements." Genome Biology 19 (November 2018): 199 © 2018 The Author(s)
Version
Final published version
Abstract
Transposable elements (TEs) are major components of eukaryotic genomes. However, the extent of their impact on genome evolution, function, and disease remain a matter of intense interrogation. The rise of genomics and large-scale functional assays has shed new light on the multi-faceted activities of TEs and implies that they should no longer be marginalized. Here, we introduce the fundamental properties of TEs and their complex interactions with their cellular environment, which are crucial to understanding their impact and manifold consequences for organismal biology. While we draw examples primarily from mammalian systems, the core concepts outlined here are relevant to a broad range of organisms.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1186/s13059-018-1577-z
