Asymmetric Hydroarylation of Vinylarenes Using a Synergistic Combination of CuH and Pd Catalysis
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jacs.6b04566.pdf
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1.07 MB
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Author(s)
Friis, Stig During
Pirnot, Michael T
Buchwald, Stephen Leffler
Date Issued
June 2016
Journal
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Citation
Friis, Stig D., Michael T. Pirnot, and Buchwald, Stephen L. “Asymmetric Hydroarylation of Vinylarenes Using a Synergistic Combination of CuH and Pd Catalysis.” Journal of the American Chemical Society 138, 27 (July 2016): 8372–8375 © 2016 American Chemical Society
Version
Final published version
Abstract
Detailed in this Communication is the enantioselective synthesis of 1,1-diarylalkanes, a structure found in a range of pharmaceutical drug agents and natural products, through the employment of copper(I) hydride and palladium catalysis. Judicious choice of ligand for both Cu and Pd enabled this hydroarylation protocol to work for an extensive array of aryl bromides and styrenes, including β-substituted vinylarenes and six-membered heterocycles, under relatively mild conditions.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/JACS.6B04566
