Dietary Factors Modulate Helicobacter-associated Gastric Cancer in Rodent Models
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Fox_Dietary factors.pdf
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2.56 MB
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Author(s)
Fox, James G.
Wang, Timothy C.
Date Issued
December 2013
Journal
Toxicologic Pathology
Publisher
Sage Publications
Citation
Fox, J. G., and T. C. Wang. “Dietary Factors Modulate Helicobacter-Associated Gastric Cancer in Rodent Models.” Toxicologic Pathology 42, no. 1 (December 3, 2013): 162–181.
Version
Author's final manuscript
Abstract
Since its discovery in 1982, the global importance of Helicobacter pylori–induced disease, particularly in developing countries, remains high. The use of rodent models, particularly mice, and the unanticipated usefulness of the gerbil to study H. pylori pathogenesis have been used extensively to study the interactions of the host, the pathogen, and the environmental conditions influencing the outcome of persistent H. pylori infection. Dietary factors in humans are increasingly recognized as being important factors in modulating progression and severity of H. pylori–induced gastric cancer. Studies using rodent models to verify and help explain mechanisms whereby various dietary ingredients impact disease outcome should continue to be extremely productive.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Division of Comparative Medicine
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1177/0192623313512564
